海参硫酸软骨素寡糖的合成

来源 :2015年全国药物化学学术会议暨第五届中英药物化学学术会议 | 被引量 : 0次 | 上传用户:jy02132679
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  海参硫酸软骨素(sea cucumber chondroitin sulfate)最早由Vieira 和 Mour(a)o[1]小组于1988 年从Ludwigothurea grisea 海参体壁中分离得到。
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Recent studies have established that histone deacetylase 6(HDAC6)is associated with oncology,immune-inflammatory and neurodegenerative disorders.[1] Besides,selective histone deacetylase 6 inhibitors
近年来,基于氨基苯腈配体的银(I)配合物引起了人们的关注。本文以卤素(F,Cl)取代的氨基苯腈为配体,与硝酸银合成了两个相应的银(I)配合物[Ag(L1)2]NO3(1),[Ag(L2)NO3](2)(L1 = 4-amino-3-fluorobenzonitrile,L2 = 4-amino-3-chlorobenzonitrile)。这两个配合物通过X-ray 进行了晶体结构表征。
Histone lysine-specific demethylase 1(LSD1)is an FAD-dependent demethylase that catalyzes the removal of methyl groups from lysine-4 in histone H3,thereby mediating gene repression[1].
Chemical modification,consisting of phosphorodithioate(PS2)and 2-O-Methyl(2-OMe)MePS2 on one nucleotide that significantly enhances potency and resistance to degradation for various siRNAs.
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Benzimidazole moiety is a structural isostere of naturally occurring nucleotides and it has been extensively utilized as a drug scaffold in the medicinal chemistry.
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Histone lysine specific demethylase 1(LSD1)is the first identified histone demethylase,which can demethylate mono-and di-methylated histon3 lysine 4(H3K41/2)and histone 3 lysine 9(H3K9me1/2)when it is
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Lysine specific demethylase 1(LSD1)selectively removes methyl groups from monoand dimethylated histone 3 lysine 4(H3K4),lead to gene silencing[1].