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  5. Molecular Identity and Regulation of Sodium-leak Channels on the Plasma and Endolysosomal Membranes

Molecular Identity and Regulation of Sodium-leak Channels on the Plasma and Endolysosomal Membranes

来源 :The 4th International Ion Channel Conference(第四届国际离子通道会议) | 被引量 : 0次 | 上传用户：QQ379043463
【摘 要】
：
Both plasma and organelle membranes are known to have basal (leak) Na+ permeability, but the molecular basis for the leak and its regulation are poorly understood.We discovered that NALCN and TPCs, at
【作 者】
：
Dejian Ren 
【机 构】
：
University of Pennsylvania, USA
【出 处】
：
The 4th International Ion Channel Conference(第四届国际离子通道会议)
【发表日期】
：
2013年2期
【关键词】
：
NALCN TPC Na+-leak channel 
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Both plasma and organelle membranes are known to have basal (leak) Na+ permeability, but the molecular basis for the leak and its regulation are poorly understood.We discovered that NALCN and TPCs, atypical members in the Nav/Cav channel superfamily, contribute the basal Na+ conductances on the plasma membrane and endolysosomal membrane, respectively.
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