【摘 要】
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Objective To characterize the blood oxygen level-dependent (BOLD) fluctuations in benign and malignant musculoskeletal tumors via power spectrum analyses in pre-established low-frequency bands. Materi
【机 构】
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The Third Hospital of Hebei Medical University;Hebei Province Biomechanical Key Laborary of Orthoped
【出 处】
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中华放射学学术大会2016、中华医学会第23次全国放射学学术大会暨中华医学会第24次全国影像技术学术大会
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Objective To characterize the blood oxygen level-dependent (BOLD) fluctuations in benign and malignant musculoskeletal tumors via power spectrum analyses in pre-established low-frequency bands. Materials and Methods BOLD fMRI and T1 weighted imaging (T1WI) were collected for 52 patients with MSK tumors at 1.5 Tesla magnetic resonance scanner. Three circular ROIs were drawn on the T1WI image in the tumors central, peripheral regions and in neighboring muscle tissue, respectively. The power spectrum of the BOLD time series within each ROI was calculated and was then divided into four frequency bands: band-1: 0.01–0.027 Hz, band-2: 0.027–0.073 Hz, band-3: 0.073–0.198 Hz, band-4: 0.198– 0.25 Hz. Analysis of Variance was conducted for each frequency band, with two factors: location of region of interest (LoR, consisting of three levels: tumor “center”, “peripheral” and “healthy tissue”) and tumor characteristic (TC, consisting of two levels: “malignant” and “benign”), then post-hoc simple effect analysis were performed if any significant effect was found.
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