The Peroxisome Proliferators-ativated Receptor Gamma(PPARG) Gene Polymorphisms and Associations with

来源 :2011中国肉牛选育改良与产业发展国际研讨会 | 被引量 : 0次 | 上传用户:zzh19860525anan
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  Peroxisome proliferators-activated receptor gamma (PPARG) is an important regulator in the regulation of adipose differentiation and development.The mutations of the PPARG in human had been proved that associated with type Ⅱ diabetes, fat distribution and body weight.The functional importance of the PPARG makes it a good candidate to search molecular markers in Marker Assistant Selection in cattle breeding.All the mRNA region of the PPARG gene within 760 individuals of four Chinese cattle breeds was scanned, and four SNPs (-110G>C,-27C>T, +20A>G, +1344G>T) of the PPARG were detected in three Chinese indigenous cattle breeds (Qinchuan, Nangyang and Jiaxian cattle), rather than Chinese Holstein cattle.The mutations-110G>C,-27C>T and +20A>G located in the Exon1 of the PPARG, and were under linkage disequilibrium.The individuals with these three mutations had smaller body measurements.This information could help animal scientists to develop genetic markers or biomarkers to assist with beef production.
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