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通过对DNA损伤修复基因O6-甲基鸟嘌呤-DNA甲基转移酶(MGMT)基因的遗传多态性、高甲基化及蛋白表达与肿瘤发生和预后关系的探讨,反映MGMT基因在肿瘤遗传学研究中的重要性。
Through the study of genetic polymorphisms, hypermethylation and protein expression of DNA damage repair gene O6-methylguanine-DNA methyltransferase (MGMT) gene and its relation with tumorigenesis and prognosis, it is indicated that the MGMT gene is involved in tumor genetics research In the importance of.