【摘 要】
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More than 30%malignant glioma will maintain the telomere length by the mechanism of alternative lengthening of telomere(ALT),but the specific mechanism of ALT is unclear.ATRX is a chromatin remodeling
【机 构】
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Department of Neurobiology,China Medical University,Shenyang,Liaoning Province,China
【出 处】
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第一届辽宁省神经科学学会学术研讨会
论文部分内容阅读
More than 30%malignant glioma will maintain the telomere length by the mechanism of alternative lengthening of telomere(ALT),but the specific mechanism of ALT is unclear.ATRX is a chromatin remodeling complex protein.Our recent studies have shown that ATRX mutation is related with ALT in brain tumors.ATRX gene was knockdown in different glioma cell lines with RNAi to study its tumorgenesis effects.Our experiments showed that the loss of ATRX changed the phenotype of ALT in JHH-GBM14 cell line by FISH staining; and that the loss of ATRX also significantly increased the expression of stemness markers in JHH-GBM14 and JHH-040821 cell lines.Our study proved that ATRX gene may play an important role in glioma ALT phenotype.It is suggested that ATRX may drive the tumor biological characteristics formation including ALT and stemness mechanism in brain tumor.
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