A designed chimeric Nav1.8 channel which can be functionally expressed in HEK293T cells

来源 :第12届生物毒素研究及医药应用学术大会 | 被引量 : 0次 | 上传用户：tanzhiming1985

【摘要】

：

　　Among the nine VGSC subtypes, Nav1.7 and Nav1.8 are attractive therapeutic targets for pains.However, the heterologous expression of Nav1.8 in mammalian cel

【作者】

：

Cheng Tang Yunxiao Zhang Xi Zhou Zhonghua Liu Songping Liang

【机构】

：

CollegeofLifeSciences,HunanNormalUniversity,Changsha,Hunan

【出处】

：

第12届生物毒素研究及医药应用学术大会

【发表日期】

：

2015年10期

【关键词】

：

Nav1.8 chimeric channel heterologous expression patch clamp

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　　Among the nine VGSC subtypes, Nav1.7 and Nav1.8 are attractive therapeutic targets for pains.However, the heterologous expression of Nav1.8 in mammalian cell lines in past years has achieved limited success.

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A designed chimeric Nav1.8 channel which can be functionally expressed in HEK293T cells

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