【摘 要】
：
目的：观察镇脑宁胶囊对动物脑微循环的影响.方法：采用静脉注射高分子右旋糖苷法致大鼠脑微循环障碍,记录出现微循环障碍的时间,以及注射20分钟后同一视野的血管流速、血液流态以及网点数.采用结扎右侧颈总动脉法致小鼠脑缺血模型,描记造模前5min、造模后10、20、30min小鼠脑血流量,计算血流量变化率.结果：镇脑宁600mg/kg、300mg/kg组能使血液流态改变减轻,流速变快,延长出现微循环障碍的
【机 构】
：
北京中医药大学,北京 100102 通化东宝药业股份有限公司,通化 130061
【出 处】
：
全国中药药理学会联合会学术交流大会
论文部分内容阅读
目的：观察镇脑宁胶囊对动物脑微循环的影响.方法：采用静脉注射高分子右旋糖苷法致大鼠脑微循环障碍,记录出现微循环障碍的时间,以及注射20分钟后同一视野的血管流速、血液流态以及网点数.采用结扎右侧颈总动脉法致小鼠脑缺血模型,描记造模前5min、造模后10、20、30min小鼠脑血流量,计算血流量变化率.结果：镇脑宁600mg/kg、300mg/kg组能使血液流态改变减轻,流速变快,延长出现微循环障碍的时间(P＜0.01,P＜0.05),但对于网点数的变化影响不大；镇脑宁1.5g/kg、0.75g/kg组,在结扎后10min、20min、30min内,小鼠大脑皮层血流均明显增加,与模型组相比,差异具有显著性(P＜0.01).结论：镇脑宁胶囊可以改善动物脑微循环,从而实现对偏头痛的部分治疗作用.
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