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5. Enhanced dissolution and oral bioavailability of aripiprazole nanosuspensions prepared by nanoprecip

Enhanced dissolution and oral bioavailability of aripiprazole nanosuspensions prepared by nanoprecip

来源 :2012年中国药物制剂大会——中国药学会药剂专业委员会年会、亚洲阿登制药技术研讨会暨国际控释协会中国分会年会 | 被引量 : 0次 | 上传用户：lbxs

【摘 要】

：

Reducing the particle size of drugs to produce nanosuspensions or nanocrystals,is quite advantageous for poorly soluble drugs to enhance their bioavailability.Due to the deficiency of conventional nan

【作 者】

：

Yin Xu Mingzhu Shangguan Xiaoyi Liu Ruyue Lian Siyi Zheng Zongning Yin Yi Lu Wei Wu 

【机 构】

：

School of Pharmacy,Fudan University,Key Laboratory of Smart Drug Delivery of Ministry of Education a

【出 处】

：

2012年中国药物制剂大会——中国药学会药剂专业委员会年会、亚洲阿登制药技术研讨会暨国际控释协会中国分会年会

【发表日期】

：

2012年10期

【关键词】

：

nanosuspensions acid-base neutralization aripiprazole solubility dissolution ora 

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　　Reducing the particle size of drugs to produce nanosuspensions or nanocrystals,is quite advantageous for poorly soluble drugs to enhance their bioavailability.Due to the deficiency of conventional nanoprecipitation techniques,it is desired to explore relatively mild procedures to produce robust nanosuspensions.

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