Introduction Microglial activation contributes to neuroinflammation and neuronal damages in neurodegenerative disorders including Alzheimers and Parkinsons diseases.
Alzheimers disease(AD)is an age-related neurodegenerative disorder,and characterized by chronic progressive deterioration of cognition,learning and memory.
Abnormal α-synuclein(α-syn)expression and aggregation have been implicated in the pathogenesis of Parkinsons disease(PD),dementia with Lewy bodies(DLB),and Alzheimers disease(AD).
Aging is associated with an increased risk for Parkinsons disease(PD)and dementia with Lewy bodies(DLB),in which alpha-synuclein(α-syn)oligomerization plays key pathogenic roles.