Profiling of Small Noncoding RNAs in Mouse Oocyte and Early Embryos

来源 :中国细胞生物学学会2015年全国学术大会 | 被引量 : 0次 | 上传用户:Mr_Zhou
下载到本地 , 更方便阅读
声明 : 本文档内容版权归属内容提供方 , 如果您对本文有版权争议 , 可与客服联系进行内容授权或下架
论文部分内容阅读
  Small non-coding RNAs (ncRNA) play important roles in diverse cellular processes, but little is known about their identities and expression dynamics during fertilization and early embryonic development in mammalians due to difficulties in obtain large numbers of early embryonic cells.
其他文献
Carcinogenesis by chronic exposure to arsenic in the environment has been widely concerned.However, the mechanism of cancer formation and progression induced by chronic arsenic exposure is still not c
Cancer cells use aerobic glycolysis preferentially for energy provision, and this metabolic change is critical for tumor growth.Smad2 and Smad3 are components of the transforming growth factor β (TGF-
The transcription factor of Interferon Regulatory Factor 7 (IRF7) is not only involved in immune responses but also oncogenesis, and the regulation of oncogenesis is cell type dependent.
Cucurbitacin B (Cuc B), a tetracyclic triterpene, is an extract from cucurbitaceous plants and has been demonstrated possessing potent anti-cancer activities.
Oridonin, a complexent-kaurane diterpenoid isolated from the traditional Chinese herb Isodon rubescens, has been demonstrated great potential in the treatment of various human cancers due to its uniqu
Piper longum L.is a well-known traditional antihyperlipidemic medicine in China, the constituents extracted from the fruit of P.longum yielded piperine (GBO) and pipernonaline.
肿瘤及肿瘤干细胞的发生与成体干细胞衰老、分化异常导致的恶性转化密切相关.DNA损伤应答系统是细胞维持基因组稳定的主要防御机制,近来在P53等DNA损伤应答分子的研究中发现DNA损伤应答系统在干细胞自稳中发挥多层面作用.XPC作为重要的DNA修复与细胞周期调控分子,其异常可导致多种肿瘤发生,但XPC在干细胞自稳中的角色尚未探及.
DNA双链断裂(DSBs)是一种严重的DNA损伤类型.为了维持基因组的稳定性,真核生物的DNA通过与组蛋白结合进化出更为复杂紧密的染色质结构.然而这种致密的结构对于DNA的转录,复制和修复等代谢过程是一个巨大的障碍.BRG1是染色质重塑复合物SWI/SNF的核心亚基,它具有ATP水解酶活性.已有研究发现BRG1与肿瘤发生和基因组不稳定性具有重要联系.
Spontaneous regression of neuroblastoma (NB) resembles the developmentally regulated programmed cell death (PCD) of sympathetic neurons.
Extracellular proteins are vital for cell activities, including cell migration.Calumenin is highly conserved among eukaryotes, but its functions are largely unclear.