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  5. An individual variation study of electroacupuncture analgesia in rats using microarray

An individual variation study of electroacupuncture analgesia in rats using microarray

来源 :中国神经科学学会第四次会员代表大会暨第七届全国学术会议(The 7th Biennial Meeting and the | 被引量 : 0次 | 上传用户：wjsxyxjc
【摘 要】
：
The aim of the present study is to probe candidate genes which were involved in the electro-acupuncture (EA) analgesia and to understand the molecular basis of the individual difference of EA analgesi
【作 者】
：
Yu-Zhen GAO Shi-Yu GUO Qi-Zhang YIN Tadashi HISAMITSU Xing-Hong JIANG 
【机 构】
：
Department of Neurobiology, School of Medicine, Soochow University, Suzhou 215123, China ;Laboratory
【出 处】
：
中国神经科学学会第四次会员代表大会暨第七届全国学术会议(The 7th Biennial Meeting and the
【发表日期】
：
2007年12期
【关键词】
：
individual difference electroacupuncture analgesia rat microarray 
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　　The aim of the present study is to probe candidate genes which were involved in the electro-acupuncture (EA) analgesia and to understand the molecular basis of the individual difference of EA analgesia in rats.EA stimulation at the ST36 acupoints (Zusanli) was applied for 1 h at 1 Hz and nociceptive sensitivity was assessed by recording the tail-flick latency (TFL) induced by radiant heat.Responders and non-responders were determined by Pain Threshold Increase Rate (PTIR) in which the PTIR of responders is more than 30% while the PTIR of non-responders is less than 25% of control.We compared hypothalamus transcriptional profiles of responders with that of non-responders using oligonucleotide microarray.
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