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  5. Effects of AGAP, a analgesic-antitumor peptide, on voltage-gated ion channels in acutely isolated ra

Effects of AGAP, a analgesic-antitumor peptide, on voltage-gated ion channels in acutely isolated ra

来源 :The 12th Meeting of the Asia Pacific Federation of Pharmacol | 被引量 : 0次 | 上传用户：Liuyuly
【摘 要】
：
Aim: Previous studies showed that analgesic-antitumor peptide (AGAP) has analgesic activities tested.In this study, the effects of AGAP on ion channels including VGSC, VGCC and VGPC were investigated
【作 者】
：
Xi-fang LIU Chun-li LI Jing-hai ZHANG Yan-feng LIU Chun-fu WU 
【机 构】
：
Department of Pharmacology, Shenyang Pharmaceutical University, Shenyang 110016, China
【出 处】
：
The 12th Meeting of the Asia Pacific Federation of Pharmacol
【发表日期】
：
2013年4期
【关键词】
：
AGAP VGSC Nav1.8 TTX-R sodium channels VGCC 
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Aim: Previous studies showed that analgesic-antitumor peptide (AGAP) has analgesic activities tested.In this study, the effects of AGAP on ion channels including VGSC, VGCC and VGPC were investigated in acutely isolated rat DRG neurons.Methods: Whole-cell patch-clamping was used to record the voltage-gated Na+ currents, voltage-gated Ca2+ currents and voltage-gated K+ currents in acutely isolated rat small DRG neurons.
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