睡眠呼吸暂停综合征(SAS)是一种常见的与睡眠相关的呼吸障碍疾病。大量的研究表明,SAS是多种疾病的独立危险因素,可导致心、脑、肾及血液等器官或系统损害。建立理想的SAS动物模型对研究其发病机制及治疗有重要意义。目前,国内外学者尝试用不同动物,通过不同的环节模拟人类SAS患者的病理生理状态,其中啮齿动物是最常用的造模动物。本文就啮齿类SAS动物模型的建立方法及优缺点进行综述。 Sleep apnea syndrome (SAS) is a common sleep-related respiratory disorder. Numerous studies have shown that SAS is an independent risk factor for a variety of diseases and can lead to damage to organs and systems such as heart, brain, kidney and blood. Establishing an ideal animal model of SAS is of great importance for studying its pathogenesis and treatment. At present, domestic and foreign scholars try to use different animals to simulate the pathophysiology of human SAS patients through different aspects, of which rodents are the most commonly used animal model. This article reviews the establishment of rodent SAS animal models and their advantages and disadvantages.