Targeted migration of engrafted neural precursor cells derived from ES cells and their differentiati

来源 :中国神经科学学会第四次会员代表大会暨第七届全国学术会议(The 7th Biennial Meeting and the | 被引量 : 0次 | 上传用户：FSM0225

【摘要】

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【作者】

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Jun TANG Hai-Wei XU Xiao-Tang FAN Zhi-Fang LI Da-Bing LI Li YANG Guang-Ji ZHOU

【机构】

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Department of Physiology, Third Military Medical University, Chongqing, 400038, China

【出处】

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中国神经科学学会第四次会员代表大会暨第七届全国学术会议(The 7th Biennial Meeting and the

【发表日期】

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2007年12期

【关键词】

：

Embryonic stem cells β-amyloid peptide Cell transplantation Differentiation Migr

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　　Neural stem cells (NSCs) could be applied for neuronal regeneration and structural brain repair only when they migrate within the CNS and reach the precise regions where neuronal replacement is required.When the brain was injuried,NSCs in the hippocampus and subventxicular zone (SVZ) of the adult changed their migratory route and moved toward the injury site.In present study,we observed the migration and differentiation of neural precursor cells (NPCs) derived from murine embryonic stem (ES) cells when transplanted into the Aβ-injuried hippocampus of rats.Correlation between migration distance and differentiation ratio of the engrafted NPCs was also analyzed.Murine ES cell line MESPU35,which expressing enhanced green fluorescent protein (EGFP),was differentiated into nestin-positive NPCs with modified serumfree methods before transplantation.

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