The resistance mechanisms that limit the efficacy of retinoid therapy in cancer are poorly understood.Sphingosine kinase 2(SphK2)is a highly conserved enzyme that is mainly located in the nucleus and
It is demonstrated that breast cancer cells secrete DJ-1.However,the physiological and pathological significance of DJ-1 secretion is not clearly understood.In fact,a high level of DJ-1 protein has be
Prostate cancer(PCa)is one of the most common cancers in men and is still one of the most intriguing challenge in oncology due to the lack of knowledge of disease progression mechanisms on the molecul
FOXC1 is a member of Forkhead box transcription factors that participates in embryonic development and tumorigenesis.Our previous study demonstrated that FOXC1 was highly expressed in triple-negative
Cancers figure among the leading causes of morbidity and mortality worldwide.The number of new cases is expected to rise by about 70%over the next 2 decades.
The present study aimed to observe the reversing effects of neferine on multidrug resistance of BEL-7402/CDDP and BEL-7402/FOL cells,as well as a preliminary investigation on their mechanism of action
The recent Middle East respiratory syndrome coronavirus(MERS-CoV),Ebola and Zika virus outbreaks exemplify the continued threat of(re-)emerging viruses to human health,and our inability to rapidly dev
Biofilm formation ability of A.baumannii is associated with long-term survival in hospital environments or equipment and provides resistance to antibiotics.
The present study aimed to investigate the molecular resistant characteristics of A.baumannii to biocides.Forty-seven clinical isolates were collected and their susceptibility to commonly used biocide