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目的 为肿瘤的治疗提供理论基础,并寻找到新的治疗靶点.方法 临床病人基因测序,端粒检测.结果 Loss of histone H3.3-specific chaperone component ATRX or its partner DAXXfrequently occurs in human cancers that employ alternative lengthening of telomeres(ALT)for chromosomal end protection,yet the underlying mechanism remains unclear.