【摘 要】
：
N-α-acetyltransferase 10 protein, Naa10p, is an N-acetyltransferase known to be involved in cell cycle control.We found that Naa10p was expressed lower in
【机 构】
：
Molecular and Cellular Cancer Biology Laboratory, Institute of Toxicology, NTU Taiwan
【出 处】
：
BITs 3rd Annual World Cancer Congress-2012(2012第五届世界癌症大会)
论文部分内容阅读
N-α-acetyltransferase 10 protein, Naa10p, is an N-acetyltransferase known to be involved in cell cycle control.We found that Naa10p was expressed lower in varieties of malignancies with lymph node metastasis compared with nonlymph node metastasis.Higher Naa1 0p expression correlates the survival of lung cancer patients.Naa10p significantly suppressed migration, tumor growth, and metastasis independent of its enzymatic activity.Instead, Naa1 0p binds to the GIT-binding domain of PIX, thereby preventing the formation of the GIT-PIX-Paxillin complex, resulting in reduced intrinsic Cdc42/Rac1 activity and decreased cell migration.Forced expression of PIX in Naa10-transfected tumor cells restored the migration and metastasis ability.We suggest that Naa10p functions as a tumor metastasis suppressor by disrupting the migratory complex, PIX-GIT-Paxillin, in cancer cells.
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