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Aim: The aim of the the present study was to investigate the effects of FLC, a plantderived compound, on the acute liver injury in mice induced by LPS/D-GalN.Methods: A mixture of LPS/D-GalN was administered intraperitoneally to prepare an animal model of acute liver injury.FLC (10, 20, and 40 mg/kg) were orally administered 0.5 h after LPS/D-GalN injected in mice.The survival rate was measured in 48 h after LPS/GalN injection.Blood and liver tissue samples were collected 6h after LPS/GaiN injection.