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目的探讨人巨细胞病毒(HCMV)、柯萨奇B组病毒(CVB)及ICA、GADAb、FPG检测多因素与糖尿病的关系。方法选取我院2011~2013年住院或门诊糖尿病患者100例,其中,T1DM(T1DM组)、T2DM(T2DM组)患者各50例。另选取健康对照(NC组)者50名。检测各组ICA、GADAb、人巨细胞病毒lgM抗体(HCMV-lgM)、人巨细胞病毒IgG抗体(HCMV-IgG)、柯萨奇B组病毒IgM抗体(CVB-IgM)及FPG水平。结果抗HCMV-IgM、抗HCMV-IgG、抗CVB-IgM、ICA、GADA阳性例数(阳性率)T1DM组分别为16(32%)、36(72%)、22(44%)、29(58%)、13(26%),T2DM组分别为3(6%)、21(42%)、4(8%)、12(24%)、1(2%),NC组分别为1(2%)、11(22%)、1(2%)、1(2%)、0(0%)(P<0.05)。与NC组比较,T2DM组抗HCMV-IgG、ICA抗体检测阳性结果差异有统计学意义(P<0.05)。3组FPG水平比较差异有统计学意义(P<0.05)。结论联合检测HCMV、CVB抗体及ICA、GADAb、FPG对糖尿病患者的诊疗具有重要价值。
Objective To investigate the relationship between multifactorial detection of human cytomegalovirus (HCMV), Coxsackie virus B (CVB), ICA, GADAb and FPG and diabetes mellitus. Methods 100 cases of inpatients or outpatients with diabetes from 2011 to 2013 in our hospital were selected, including 50 cases of T1DM (T1DM group) and T2DM (T2DM group). Another healthy control group (NC group) were 50. The levels of ICA, GADAb, HCMV-lgM, HCMV-IgG, CVB IgM and FPG in each group were detected. Results The positive rate of anti-HCMV-IgM, anti-HCMV-IgG, anti-CVB-IgM, ICA and GADA were 16 (32%), 36 (72%), 22 (44%) and 29 58%), 13 (26%) and T2DM group were 3 (6%), 21 (42%), 4 (8%), 12 (24%) and 1 2%), 11 (22%), 1 (2%), 1 (2%), 0 (0%) (P <0.05). Compared with NC group, the positive results of anti-HCMV-IgG and ICA antibody in T2DM group were statistically significant (P <0.05). There were significant differences in FPG levels between the three groups (P <0.05). Conclusion Combined detection of HCMV and CVB antibodies, ICA, GADAb and FPG is of great value in the diagnosis and treatment of diabetic patients.