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采用常规切片、电镜和免疫组织化学方法，对由沥青烟气诱发的小鼠肺类癌的病理组织学、免疫组织化学和超微结构特征进行了研究。结果显示：小鼠肺类癌可分为５种组织学类型，即巢状型、乳头状型、腺样型、不典型型和混合型；免疫组化标记中，神经元特异性烯醇化酶（ＮＳＥ）、嗜铬颗粒蛋白Ａ（ＣＨＧ－Ａ）和突触囊泡蛋白（ＳＹ）阳性率较高，而角蛋白（ＨＫ２）、上皮细胞膜抗原（ＥＭＡ）和癌胚抗原（ＣＥＡ）阳性率较低；电镜观察可见类癌细胞中有典型的神经内分泌颗粒。提示：实验性小鼠肺类癌的病变特点与人类肺类癌相似。
The histopathology, immunohistochemistry and ultrastructural features of mouse lung carcinoid cells induced by bitumen smoke were studied by routine sectioning, electron microscopy and immunohistochemical methods. The results showed that mouse lung carcinoids can be divided into five histological types: nested, papillary, adenoid, atypical, and mixed; neuron-specific enolase in immunohistochemical markers. (NSE), Chromogranin A (CHG-A), and Synapsin vesicle protein (SY) are positive, while keratin (HK2), epithelial membrane antigen (EMA), and carcinoembryonic antigen (CEA) are positive. Lower; Electron microscopy showed typical neuroendocrine particles in cancer cells. Tip: The pathological features of experimental mouse lung carcinoids are similar to human lung carcinoids.