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近期出版的《神经病学》杂志刊登的两项研究结果显示,孕期应用丙戊酸钠(Valproale,抗惊厥和癫痫药)与胎儿畸形和神经心理学发育异常的风险增高关联;尽管另一项研究结果证实拉莫三嗪(lamotrigine)与这些危险性无关联,但因样本量太少以致无法确定两者之间的关联性。来自于美国明尼苏达癫痫症研究组的 PatriciaPenovich 博士在一次新闻发布会上评论指出,即使注册加入拉莫三嗪研究的妇女人数较多,但因妊娠妇女的数量太少而不足以对胎儿畸形与抗癫痫药物之间的关联性给出一个明确的答案;该结果在某种程度上可使妇女消除疑虑。研究人员同时亦强调如
Two recent studies published in the Journal of Neurology showed that use of sodium valproate (anticonvulsant and antiepileptic drugs) during pregnancy is associated with an increased risk of abnormal fetal and neuropsychological development, although another study The results confirm that lamotrigine is not associated with these risks, but the sample size is so small that it is not possible to determine the association between the two. Dr. Patricia Penovich, from the Minnesota Epilepsy Research Group, commented in a press briefing that even though the number of women enrolled in the lamotrigine study is high but the number of pregnant women is too small to correlate with fetal malformation and anti- The association between epilepsy drugs gives a definitive answer; this result, to some extent, can make women clear their doubts. Researchers also stressed, for example