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目的 :研究尿道压力分布图 ( U PP)与 BPH患者α-受体阻滞剂治疗效果的关系。方法 :用改良苄胺唑啉U PP试验将 BPH患者分为阳性及阴性组 ,比较 U PP诸参数之差异。结果 :45 7例 BPH患者中 143例因最大尿道闭合压 >8.83k Pa而行改良苄胺唑啉 U PP试验 ,阳性 6 4例 ,占全部病例的 14.0 %。资料完整者阳性组 ( 38例 )及阴性组 ( 2 8例 )试验前 Qmax 及 U PP诸参数无显著性差异 ( P >0 .0 5 ) ,阳性组 Qmax 增加、U PP诸参数减少有显著性差异 ( P <0 .0 1)。阳性组试验前后相比膀胱颈压及前列腺部尿道压力降低低于膜部尿道 ,试验后此两处压力相对值增高。结论 :U PP不能代替苄胺唑啉 U PP试验来预测 BPH患者α-受体阻滞剂治疗效果 ,BPH伴功能性梗阻者对α-受体阻滞剂最敏感区是远段尿道括约肌
AIM: To investigate the relationship between urethral pressure profile (U PP) and the effects of α-blockers in patients with BPH. Methods: BPH patients were divided into positive and negative groups by modified benzylazoline U PP test. The differences of U PP parameters were compared. Results: Of the 457 BPH patients, 143 cases were treated with benzylazoline U PP test because of the maximal urethral closure pressure> 8.83 kPa, which was positive in 64 cases, accounting for 14.0% of the total cases. There were no significant differences in Qmax and U PP parameters between the positive group (38 cases) and the negative group (28 cases), the positive group Qmax increased and the U PP parameters decreased significantly Sex differences (P <0.01). Positive pressure before and after the test compared with the bladder neck and urethral pressure in the prostate lower than the urethra after the test, the relative value of these two pressures increased. CONCLUSION: U PP can not replace benzylazoline U PP test to predict the effect of α-blockers in patients with BPH. The most sensitive area for α-blockers in BPH patients with functional obstruction is distal urethral sphincter