1949年Moloney首先报告了死胎并发凝直障碍的病例,当时主要的发现为血纤维蛋白原减少,并称之为死胎综合征。1950年Weiner提出这个综合征与Rh血型不合的同种免疫有关,1955年Pritchard肯定引起凝血障碍的原因是死胎而非免疫,因为各种原因引起的死胎(包括过期流产)都可能发生凝血障碍。近30年来对其发病机理深入研究的结果,认为主要是弥 Moloney first reported cases of stillbirth with coagulopathy in 1949 when the main finding was a decrease in fibrinogen called the stillbirth syndrome. In 1950, Weiner proposed that this syndrome was associated with the same type of immune incompatibility with Rh. In 1955, Pritchard affirmed the cause of coagulopathy as stillbirth rather than immunization, as clotting disorders may occur in all stillbirths, including overdue miscarriages. The past 30 years on its pathogenesis in-depth study of the results, mainly that Mi