目的：观察促皮质激素释放激素（ＣＲＨ）受体拮抗剂α－ｈｅｌｉｃａｌＣＲＨ（９－４１）与消炎痛联用对家兔内毒素（ＥＴ）性发热的影响。方法：静脉给药，用ＷＲＹ－Ｂ型微机热原测温仪测定家兔的结肠温度。结果：（１）静脉注射消炎痛（５ｍｇ／ｋｇ）明显抑制家兔ＥＴ（０２μｇ／ｋｇ）性发热，５ｈ发热反应指数（ＴＲＩ５）显著降低（Ｐ＜００５）。（２）静脉注射ＥＴ（０２μｇ／ｋｇ）引起家兔体温明显双相性升高（双相热），提前５ｍｉｎ静脉注射α－ｈｅｌｉｃａｌＣＲＨ（９－４１）（２５μｇ／ｋｇ）显著抑制家兔ＥＴ性发热，且双相热第一峰消失，第二峰明显降低。（３）α－ｈｅｌｉｃａｌＣＲＨ（９－４１）与消炎痛联合用药显著抑制家兔ＥＴ性发热，其解热效果显著超过两者单独用药。半剂量消炎痛（５ｍｇ／ｋｇ）和α－ｈｅｌｉｃａｌＣＲＨ（９－４１）联用解热组与全剂量消炎痛（１０ｍｇ／ｋｇ）解热组比较，ＴＲＩ５无显著差别（Ｐ＞００５）。结论：ＣＲＨ可能参与ＥＴ性双相热的形成抑制。ＣＲＨ受体拮抗剂与化学解热剂消炎痛联用可能是一种高效低毒的解热措施 OBJECTIVE: To observe the effect of α-helical CRH (9-41), a corticotropin-releasing hormone (CRH) receptor antagonist, and indomethacin on endotoxin (ET) fever in rabbits. Methods: Intravenous administration, using the WRY-B pyrogen thermometer to determine the temperature of the colon in rabbits. Results: (1) Intravenous indomethacin (5 mg / kg) significantly inhibited ET (02 μg / kg) febrile seizures in rabbits, and the pyrexia index (TRI5) decreased significantly at 5 hours (P <005). (2) Rabbit body temperature was significantly increased (biphasic) by intravenous injection of ET (02μg / kg), and α-helical CRH (9-41) (25μg / kg) Fever, and the first peak of biphasic heat disappeared, the second peak was significantly reduced. (3) The combination of α-helical CRH (9-41) and indomethacin significantly inhibited ET fever in rabbits, and its antipyretic effect was significantly higher than that of both alone. TRI5 showed no significant difference (P> 0.05) between half-dose indomethacin (5mg / kg) and α-helical CRH (9-41) combined with antipyretic and total antipyretic (10mg / kg) Conclusion: CRH may be involved in the formation of ET bipolar disorder. CRH receptor antagonist combined with chemical antipyretic indomethacin may be a highly efficient and low toxicity antipyretic measures