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1 孕期的生理变化妇女在妊娠期间会出现一系列的生理变化,如体液总量增加,体重、脂肪也明显增加,白蛋白水平下降,血容量增加,心输出量和肾小球滤过量也伴随增加,胃排空能力下降,易发生恶心、呕吐、消化不良现象,由于血流量增加,子宫血流量也相应增加等等。所有这些生理变化导致了药物的吸收、分布、清除等方面的相应改变。医生必须考虑到这些生理变化对药物动力学的影响,必须认识到药物的分布,影响着血浆浓度高峰的出现,同时直接影响药物的半衰期。
1 physiological changes during pregnancy will occur during pregnancy, a series of physiological changes, such as the increase in total body fluid, body weight, fat was also significantly increased, decreased albumin levels, increased blood volume, cardiac output and glomerular filtration rate also accompanied Increased, reduced gastric emptying capacity, prone to nausea, vomiting, indigestion, due to increased blood flow, uterine blood flow also increased accordingly. All of these physiological changes lead to corresponding changes in drug absorption, distribution, clearance and the like. Physicians must take into account the effects of these physiological changes on pharmacokinetics and must recognize that the drug distribution affects the appearance of peak plasma concentrations and directly affects the half-life of the drug.