本文报告10年来进行产前诊断1038例,其中孕中期羊水细胞培养724例,成功670例,发现异常胎儿19例,异常率为2.8%。绒毛直接法进行孕早期产前诊断314例,成功298例,发现异常胎儿19例(除外3例假嵌合体),异常率为6.4%。适应证中,夫妇双方之一为染色体异常者组检出异常胎儿最多,占2/3。 This article reports 1038 cases of prenatal diagnosis in 10 years. Among them, 724 cases of mid-trimester amniotic fluid cells were cultured, 670 cases were successful, and 19 cases of abnormal fetus were found, the abnormal rate was 2.8%. In the first trimester of pregnancy, 314 cases were diagnosed as prenatal diagnosis, 298 cases were successful, 19 cases were found abnormal fetus (except 3 cases), and the abnormal rate was 6.4%. Indications, one of the couple was abnormal chromosome abnormalities detected abnormal fetus group accounted for 2/3.