目的：探讨子宫内膜癌染色体不稳定性。方法：取外周血淋巴细胞体外常规培养，ＧＴＧ显带分析染色体畸变，Ｂｒｄｕ法分化染色分析ＳＣＥ改变。结果：肿瘤组（ｎ＝２２）染色体数目畸变率为１２２７％；染色体结构畸变率为６８１％；姊妹染色单体交换率为８２１±１４２，均显著高于对照组（ｎ＝１０）。结论：子宫内膜癌病人外周血淋巴细胞染色体畸变率及姊妹染色单体交换率增高，提示其染色体不稳定性增高。 Objective: To investigate the chromosomal instability of endometrial cancer. Methods: Peripheral blood lymphocytes were cultured in vitro, GTG banding was used to analyze chromosomal aberrations, and Brdu staining was used to analyze SCE changes. Results: The number of chromosomal aberrations in the tumor group (n = 22) was 1227%, the chromosome aberration rate was 681%, and the sister chromatid exchange rate was 821 ± 142, which were significantly higher than those in the control group (N = 10). Conclusion: Chromosome aberration rate and sister chromatid exchange rate of peripheral blood lymphocytes in patients with endometrial cancer increase, suggesting that the chromosome instability increased.