本文测定了31例Graves病病人的血清Ca、P、AKP,iPTH,血浆cAMP,尿Hyp以及骨矿含量(BMC)。结果示约有66.67％的病人BMC降低,而血清Ca、P、iPTH,血浆cAMP均在正常范围内,提示约有54.6％的病人血清AKP升高,但若无肝病AKP一般不超过25金氏单位;血清T_3与尿Hyp,尿Hyp与血清AKP间有正相关关系,而尿Hyp与BMC间呈负相关关系,所以血清AKP和尿Hyp可作为Graves病骨代谢负平衡的指标。这些骨质改变可能直接由甲状腺激素过多所引起。 In this study, Serum Ca, P, AKP, iPTH, plasma cAMP, urinary Hyp, and bone mineral content (BMC) were measured in 31 patients with Graves disease. The results showed that about 66.67% of patients with decreased BMC, and serum Ca, P, iPTH, plasma cAMP were within the normal range, suggesting that about 54.6% of patients with elevated serum AKP, but if no liver disease AKP generally not more than 25 Kim There was a positive correlation between serum T_3 and urinary Hyp, urinary Hyp and serum AKP, while urinary Hyp and BMC were negatively correlated, so serum AKP and urinary Hyp could be used as indicators of negative balance of bone metabolism in Graves disease. These bone changes may be directly caused by thyroid hormone excess.