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目的观察早期肠内营养对胃癌根治术患者术后恢复的影响。方法将52例行胃癌根治术的胃癌患者随机分为观察组(肠内营养)和对照组(肠外营养),每组26例,观察比较两组术后营养状况、免疫功能及术后胃肠功能恢复时间、并发症及住院时间。结果两组患者经营养治疗后白蛋白、前白蛋白及转铁蛋白等营养指标均较术前有明显改善(P<0.05),两组间各指标无统计学差异(P>0.05);观察组患者术后第8天免疫学指标包括CD3+,CD4+,CD4+/CD8+比值及IgA,IgG,IgM均较术前显著改善(P<0.05),且与对照组比较,差异有统计学意义(P<0.05);两组术后感染并发症发生率无统计学差异(P>0.05),但观察组术后排气时间及住院时间均较对照组明显缩短(P<0.05)。结论早期营养支持均能明显改善胃癌患者术后的营养状况,而肠内营养在提高机体免疫力、缩短胃肠功能恢复时间及住院日方面明显优于肠外营养。
Objective To observe the effect of early enteral nutrition on postoperative recovery of patients with gastric cancer undergoing radical operation. Methods Twenty-two gastric cancer patients undergoing radical gastrectomy were randomly divided into observation group (enteral nutrition) and control group (parenteral nutrition), with 26 cases in each group. The nutritional status, immune function, Intestinal function recovery time, complications and hospital stay. Results The nutritional indexes of albumin, prealbumin and transferrin in both groups were significantly improved after operation (P <0.05), there was no significant difference between the two groups (P> 0.05) On the 8th day after operation, the immunological indexes including the ratio of CD3 +, CD4 +, CD4 + / CD8 +, IgA, IgG and IgM were significantly improved (P <0.05), and the difference was statistically significant compared with the control group <0.05). There was no significant difference in postoperative infection complications between the two groups (P> 0.05). However, the postoperative exhaust time and hospital stay in the observation group were significantly shorter than those in the control group (P <0.05). Conclusion Early nutritional support can significantly improve the nutritional status of patients with gastric cancer, while enteral nutrition is significantly better than parenteral nutrition in improving body immunity, shortened gastrointestinal function recovery time and hospitalization days.