自从PDE5抑制剂西地那非开始应用于临床后,勃起功能障碍(ED)的治疗发生了根本性的改变。海绵体内或尿道内注射血管活性物质或阴茎假体植入的机械辅助方法等已经几乎停止应用。PDE5抑制剂他达拉非和伐地那非的出现令人关注这3种药物的有效性和副作用。Gresser U等为此对相关文献进行了回顾。西地那非已被证实是非常有效的医药产品,已经有长达6年的服药追踪随访研究。 Essential changes have taken place in the treatment of erectile dysfunction (ED) since the PDE5 inhibitor sildenafil is used clinically. Sponge or intraurethral injection of vasoactive substances or mechanical implantation of penile prosthesis methods have almost stopped using. The advent of PDE5 inhibitors, tadalafil and vardenafil, draws attention to the efficacy and side effects of these three drugs. Relevant literature has been reviewed by Gresser U et al. Sildenafil has proven to be a very effective pharmaceutical product, with up to six years of follow-up on medication.