Computer-Aided Living Polymerization Conducted under Continuous-Flow Conditions

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Continuous-flow techniques have promoted the development of synthetic chemistry due to advantages such as outstanding mass/heat transfer,on-demand scalability,improved safety,precise regulation on reaction parameters,etc.Recently,the combina-tion of flow polymerization with computer science has gained considerable interests,leading to a variety of cutting-edge synthetic techniques.This review summarizes emerging achievements realized via the integration of computer science and living flow polymerlzations,including 1) high-throughput living polymerizations in flow,2) programmable regulations of dispersity profile,se-quence and topology for polymers,3) modular design with online monitoring,as well as 4) self-optimized living polymerizations in flow.We expect that this summary will furnish informative knowledge to scientists in related directions and inspire new ideas to further empower on-demand polymer engineering with modern techniques.
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