Obtaining a continuous sedimentary record of Cenozoic East Asian paleoclimate change is key to understand the origin,evolution and driving mechanism of the East Asian monsoon and climate change.Based on the continuous Cenozoic fluvial and lacustrine sedimentary sequence in the Weihe Basin,central China,we carried out research on the content and crystal parameters of clay minerals.The paleoclimate change since the middle Eocene was reconstructed accordingly.The results show that smectite and illite are the dominant clay minerals in fluvial-lacustrine sediments of Weihe Basin.The crystallinity of illite,the chemical index of illite,the ratio of smectite to illite and chlorite decrease gradually,which indicates that chemical weathering in the Weihe River watershed stepwise weakened since the middle Eocene,under the background of a semi-arid and semi-humid climate.The formation of palygorskite may be affected by a weak diagenesis.In this case,the content of smectite and the illite crystallinity caused by the weathering in the corresponding period may be actually higher than that of the current,which indicates that the climate in the Weihe Basin region was relatively warm and humid from the middle Eocene to Pliocene.With the decrease of Cenozoic global temperature and the continuous accumulation of sediments,the intensity of chemical weathering in the Weihe Basin gradually weakened,and the East Asian monsoon climate gradually evolved until becoming dry in the Quaternary.Evidence from clay minerals also indicates that the aridification in the Weihe Basin from the late Eocene to the Oligocene may be a response to the global cooling event at the Eocene-Oligocene transition.