特定的染色体易位在人体肿瘤发生中起着重要的作用。作者观察研究了两例其白血病细胞内含有11号染色体短臂(11P13)和14号染色体长臂(14q13)之间易位的T-细胞急性淋巴母细胞白血病患者(T-ALL).将他们的白血病细胞与缺乏胸苷激酶的小鼠L-细胞进行杂交,然后采用胰蛋白酶处理和吉姆萨染色的分带技术对各体细胞杂种克隆进行核型分析,以检出易位染色体(11P~+和14~-q),同时又从继代克隆的杂种细胞中提取 Specific chromosomal translocations play an important role in human tumorigenesis. The authors observed two cases of T-cell acute lymphoblastic leukemia (T-ALL) patients whose leukemia cells contained a translocation between the short arm of chromosome 11 (11P13) and the long arm of chromosome 14 (14q13). The leukemic cells were hybridized with mouse L-cells lacking thymidine kinase, and karyotype analysis was performed on somatic hybrid clones by trypsin treatment and Giemsa staining to detect translocation chromosomes (11P~ + and 14~-q), while also extracting from hybrid cells cloned by passage