本文报告一例免疫机能受损病人发生隐球菌性蜂窝织炎。患者女性,60岁。患慢性活动性肝炎接受强的松(40毫克/日)及硫唑嘌呤(100毫克/日)治疗,因背、下肢疼痛及疲乏加重2周入院。左大腿外侧有灼热感、明显潮红,变硬及剧烈触痛,皮肤表面完整;血白细胞数12,900/立方毫米,中性89％;血清总胆红素5.1毫克％,碱性磷酸酶90IU。临床印象为慢性活动性肝炎接受免疫抑制治疗后发生大腿细菌性蜂窝织炎。开始使用氨苄青霉素2天,但仍然发热,精神异常,蜂窝织炎范围增大,改用新青霉素Ⅱ。皮下冲洗液培养,48小时内有纯培养大量新生隐球菌生长。右侧大腿相同部位亦发生大片蜂窝织炎。经甲烷胺银染色可见大量直径5～15μ芽生性真菌。其后脊液印度蓝墨水染色及培养发现新生隐球菌。血及尿培养无菌生长。停用新青霉素Ⅱ,改用二性霉素B静注及口服5-氟胞嘧啶。48小时内退热,蜂窝织炎部位触 This article reports a case of immunocompromised patients with cryptococcal cellulitis. Patient female, 60 years old. Chronic active hepatitis received prednisone (40 mg / day) and azathioprine (100 mg / day) and was admitted to the hospital for 2 weeks because of pain in the lower extremity and fatigue. Left thigh outside the burning sensation, obviously flushing, hardening and severe tenderness, the skin surface is complete; white blood cell count 12,900 / cubic mm, 89% neutral; serum total bilirubin 5.1 mg%, alkaline phosphatase 90IU. Clinical Impressions of Chronic Active Hepatitis Bimicrobial cellulitis occurs following immunosuppressive therapy. Start using ampicillin for 2 days, but still fever, mental disorders, cellulitis increased the scope of use of new penicillin. Subcutaneous wash fluid culture, a large number of pure culture within 48 hours of Cryptococcus neoformans growth. The same site of the right thigh also occurred in large areas of cellulitis. Methylamine silver staining shows a large number of diameter 5 ~ 15μ budding fungi. After the spinal fluid Indian blue ink staining and culture of C. neoformans. Blood and urine culture aseptic growth. Disable the new penicillin Ⅱ, amphotericin B switch to intravenous and oral 5-fluorocytosine. Antipyretic within 48 hours, the site of cellulitis touch