Objectives To analyses heartrate (HR) distribution of healthy adults in the southChina community and evaluate relative risk of HR tototal cause of death and cardiac cerebral vasculardeath. Methods Analytical data come from thebaseline survey and follow-up visits in the PRC-USACollaborative Study of Cardiovascular Epidemiology inurban and rural samples of Guangzhou. The baselinesurvey was initiated in 1983 and 1984, and rescannedin 1987 and 1988. Since 1991 Follow-up visits forendpoint events were carried once every two years.Average follow-up year was 16.2 from baseline to 2000.People excluded from cardiac cerebral vasculardisease, diabetes and other various chronic diseaseswere regarded as “healthy adults”. Heart rates of thesesubjects were measured on resting electrocardiogram.Endpoint evens include: total cause of death, firstattack of coronary disease and cerebral vascular events.SAS software was used for analysis. Cox ProportionalHazards model was used to evaluate the impact of HRon total death and cardiac cerebral vascular disease.Results A total of 4570 men and women aged 35-55years from urban and rural Guangzhou wereinvestigated. 3493 healthy subjects were enrolled in theanalysis, including 1694 men and 1799 women. Meanof the HR is (67.9±10.6) beats/min (bpm) in thewhole population, (66.3±10.7)bpm in men and (69.3±10.4) in women. The 5th percentile of the HR was 51 inmen and 54 in women. The 95th percentile of the HRwas 85 in men and 88 in women. Single correlationanalysis showed there was negative relationshipbetween age and HR, but it was only statisticalsignificant in female. Analysis with Cox ProportionalHazards model show that HR < 50 bpm tops the risk oftotal causes of death (1.725) and HR 50-59 bpmdecreased the risk of total causes of death (0.843).Relative risk of cardiac cerebral vascular eventsexceeds 1 when HR < 50 and>90 bpm (1.486 and7.008 respectively). It was less than 1 in other groupsbut there was no significant difference between eachgroup. Conclusions Traditional normal range of HRin adult should be adjusted. In certain extent lower HRis advantageous to decrease cardiac cerebral vascularevents, total causes of death and has better prognosis. Objectives To analyze heart rate (HR) distribution of healthy adults in the southChina community and evaluate relative risk of HR tototal cause of death and cardiac cerebral vascular death. Methods Analytical data come from the baseline survey and follow-up visits in the PRC-US ACOLlaborative Study of Cardiovascular Epidemiology inurban and rural samples of Guangzhou. The baselinesurvey was initiated in 1983 and 1984, and rescannedin 1987 and 1988. Since 1991 Follow-up visits forendpoint events were carried once every two years. Average follow-up year was 16.2 from baseline to 2000. People excluded from cardiac cerebral vascular, diabetes and other various chronic diseases were called as “healthy adults.” Heart rates of thesesubjects were measured on resting electrocardiogram. Endpoint evens include: total cause of death, firstattack of coronary disease and cerebral vascular events. SAS software was used for analysis. Cox ProportionalHazards model was used to evaluate the impact of HR of total death and cardiac cerebral vascular disease. Results A total of 4570 men and women aged 35-55 years from urban and rural Guangzhou were were. 3493 healthy subjects were enrolled in the analysis, including 1694 men and 1799 women. Mean of the HR is (67.9 ± The 5th percentile of the HR was 51 inmen and 54 in women. The 95th percentile of the HRwas 85 (66.3 ± 10.7) bpm in men and (69.3 ± 10.4) in women. in men and 88 in women. Single correlation analysis showed there was negative relationship between age and HR, but it was only statisticalsignant in female. Analysis with Cox ProportionalHazards model show that HR <50 bpm tops the risk of total causes of death (1.725) and HR 50 It was less than 1 in other groups but there was no significant (-58 bpm) difference between eachg roup. Conclusions Traditional normal range of HRin adults should be adjusted. In certain extent lower HRis advantageous to decrease cardiac cerebral vascularevents, total causes of death and has better prognosis.