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将大学生２４４名血清感染指标均阴性者随机分为３组，分别接种三步灭活和加热灭活疫苗，并设对照组，进行二年的免疫效果的对比观察。结果两疫笛水平一致。首免后７个月（全程免疫后），前者抗－ＨＢｓ阳转率为８９；７％，几何平均滴度５４９．６９ｍＩＵ／ｍｌ。后者不同批号抗－ＨＢｓ阳转率各为１００％和９３．３％，１４μｇ组显著高于前者同剂量组外，１、２年均无差异。几何平均滴度各为５６６．０５和６０１．０７ｍＩＵ／ｍｌ。１、２年结果两疫苗也无显著差异。免后７个月的保护率前者为９１．５％，后者为８８．６％，也无显著差异。两种疫苗的反应均较轻微。
244 college students were negative indicators of serum infection were randomly divided into 3 groups were inoculated with three-step inactivation and heat inactivated vaccine, and control group for two years of comparative observation of the immune effect. The results of the two flute level consistent. Seven months after the first immunization (after full immunization), the former anti-HBs positive conversion rate of 89; 7%, the geometric mean titer of 549.69mIU / ml. The latter anti-HBs positive rate of different batches were 100% and 93.3%, 14μg group was significantly higher than the former same dose group, no difference for 1, 2 years. The geometric mean titers were 566.05 and 601.07 mIU / ml, respectively. 1, 2 year results of the two vaccines also no significant difference. The first seven months after the protection rate of 91.5% for the former, the latter was 88.6%, no significant difference. The response to both vaccines was mild.