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唾液分泌受到抑制时,口腔粘膜发生炎症性变化引起口腔干燥症,伴有烧灼感、疼痛、味觉异常、吞咽困难等。唾液分泌减少的原因有精神性,症状性,精神药副作用,放射线损害及增龄变化等。L-半胱氨酸乙酯的活性巯基(-SH)使蛋白的二硫基结合断裂,唾液粘度降低,具有抗水肿、修复组织及使分泌物易于排出的作用。治疗方法及病例:每天用 L-半胱氨酸乙酯600mg,分3次服,每次2片。给药8周后进行综合判定。用无味口香糖刺激10分钟,测定混合唾液量。治疗32例病人(女24例,男8例),平均年龄60.9岁。其中,精神性(唾液量正常,但主诉口腔干燥)15例,症状性(Sj(?)gren 综合征、Mikulicz 综合征或增龄所致)9例,药物性及放射线损害所致各4例。
When saliva secretion is suppressed, an inflammatory change in the oral mucosa causes xerophthalmia accompanied with a burning sensation, pain, abnormal taste, difficulty swallowing, and the like. Salivary secretion decreased due to spiritual, symptomatic, psychiatric side effects, radiation damage and aging changes. The activity of L-cysteine ethyl ester Thiol (-SH) breaks the disulfide bond of the protein and reduces the viscosity of saliva. It has the function of resisting edema, repairing tissue and excreting secretions easily. Treatment methods and cases: Daily use of L-cysteine ethyl 600mg, 3 times service, each 2. After 8 weeks of administration, a comprehensive judgment was made. Stimulated with tasteless chewing gum for 10 minutes, the amount of mixed saliva was measured. Treatment of 32 patients (24 females, 8 males), mean age 60.9 years old. Among them, there were 15 cases of psychic (normal saliva volume, but complained of oral dryness), 9 cases of symptomatic (Sj (?) Gren syndrome, Mikulicz syndrome or aging), 4 cases of drug induced and radiation damage .