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目的探讨高通量血液透析与常规血液透析治疗慢性尿毒症患者的临床效果。方法选取2013年8月至2015年8月在辽宁省沈阳市红十字会医院接受治疗的慢性尿毒症患者70例为研究对象,按随机数字表法分为对照组和观察组,每组35例。对照组患者给予常规血液透析治疗,观察组患者给予高通量血液透析治疗,比较两组患者的治疗效果和肾功能相关指标。结果对照组患者的治疗有效率为为68.6%,低于观察组的88.6%,差异有统计学意义(P<0.05);对照组患者并发症发生率为25.7%,显著高于观察组的5.7%,差异有统计学意义(P<0.05)。两组患者治疗前血尿素氮、血肌酐、β_2微球蛋白及尿素清除指数比较,差异无统计学意义(P>0.05);治疗3个月后两组患者上述指标均得到改善,观察组患者β_2微球蛋白及尿素清除指数改善效果较对照组更为明显,差异均有统计学意义(均P<0.05)。结论采用高通量血液透析治疗慢性尿毒症可以有效改善患者临床症状,疗效明显。
Objective To investigate the clinical effects of high-throughput hemodialysis and routine hemodialysis on patients with chronic uremia. Methods Seventy patients with chronic uremia who were treated at Shenyang Red Cross Hospital of Shenyang, Liaoning Province from August 2013 to August 2015 were selected as control group and control group according to the random number table method, with 35 cases in each group . The patients in the control group were given conventional hemodialysis. The patients in the observation group were given high-flux hemodialysis. The therapeutic effects and the indexes of renal function were compared between the two groups. Results The effective rate of the control group was 68.6%, which was lower than that of the observation group (88.6%), the difference was statistically significant (P <0.05). The incidence of complications in the control group was 25.7%, which was significantly higher than that of the observation group %, The difference was statistically significant (P <0.05). There was no significant difference in blood urea nitrogen, serum creatinine, β_2 microglobulin and urea clearance index between the two groups before treatment (P> 0.05). After 3 months of treatment, the above indexes were improved in both groups. In the observation group β 2 microglobulin and urea clearance index improved more obvious than the control group, the differences were statistically significant (P <0.05). Conclusion High-throughput hemodialysis treatment of chronic uremia can effectively improve the clinical symptoms of patients with obvious curative effect.