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目的:探讨比索洛尔和培哚普利联合治疗舒张性心功能不全较培哚普利治疗组可明显改善心脏舒张功能。方法:将61例舒张性心力衰竭患者单盲随机分为治疗组与对照组,对照组30例采用培哚普利、利尿剂、硝酸酯类、醛固酮抑制剂抗心衰治疗,治疗组在以上基础上加用比索洛尔,疗程3～4wK。比较2组临床疗效、心脏彩超左室舒张功能等指标。结果:治疗组总有效率93%。明显优于对照组的67%(p<0.05),在改善左室舒张功能指标方面治疗组也明显优于对照组(p<0.05)。结论:比索洛尔、培哚普利联用治疗舒张功能不全患者能有效缓解症状。
OBJECTIVE: To investigate the effect of bisoprolol and perindopril in treating diastolic heart failure compared with perindopril treatment group. Methods: Sixty-one patients with diastolic heart failure were randomly divided into treatment group and control group. 30 patients in control group were treated with perindopril, diuretics, nitrates and aldosterone inhibitors, Based on the addition of bisoprolol, treatment 3 ~ 4wK. The clinical curative effect, left ventricular diastolic function of cardiac ultrasonography and other indexes were compared. Results: The total effective rate was 93% in the treatment group. Significantly higher than the control group 67% (p <0.05), in improving the left ventricular diastolic function in the treatment group was also significantly better than the control group (p <0.05). Conclusion: Bisoprolol and perindopril can effectively relieve symptoms in patients with diastolic dysfunction.