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利用微通道法乳化技术原理,研制了一个可拆卸T型玻璃微通道装置,以聚乙烯醇水溶液为连续相,聚(乳酸-co-羟基乙酸)(PLGA)的二氯甲烷溶液为分散相,制备了单分散的PLGA微球.考察了乳化剂用量、连续相和分散相流速以及PLGA浓度对形成的液滴平均粒径和变异系数(CV值)的影响.结果表明,增大乳化剂用量,提高连续相流速或降低分散相流速,制备得到的PLGA微球直径减小;分散相浓度在5～20 g/L之间变化时,其对微球直径的影响有限.PLGA微球表面光滑无孔,且内部是实心的.用本装置制备得到的PLGA微球,其粒径范围在30～200μm之间,CV值在15%以下,最低可至3%.该方法可使用挥发性有机溶剂作为分散相而且能避免微球制备时易堵塞等问题,可应用于药物缓控释领域中微米级单分散微球的制备.
A novel detachable T-glass microchannel device was developed by using microchannel emulsification technology. The aqueous solution of poly (vinyl alcohol) as the continuous phase and the poly (lactic acid-co-glycolic acid) (PLGA) Monodisperse PLGA microspheres were prepared.The effects of the amount of emulsifier, the flow rate of continuous phase and disperse phase, and the concentration of PLGA on the average particle diameter and coefficient of variation (CV) of the formed droplets were investigated.The results showed that increasing the amount of emulsifier , Increasing the flow rate of the continuous phase or decreasing the flow velocity of the dispersed phase, the diameter of the prepared PLGA microspheres is reduced; when the dispersion phase concentration is varied from 5 to 20 g / L, the microspheres have a limited influence on the diameter of the microspheres. Non-porous, and internal solid PLGA microspheres prepared by the device, the particle size range between 30 ~ 200μm, the CV value of less than 15%, the lowest to 3%. The method can be used volatile organic As a disperse phase, the solvent can avoid the problems of easy plugging when the microspheres are prepared, and can be used for preparing the micrometer-sized monodisperse microspheres in the field of controlled release of drugs.