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研究慢性活动性肝炎(以下简称CAH)与人类白细胞抗原(HLA)的关系是研究CAH遗传易感性的一个重要方面。70年代以来已有不少文献报告在CAH病人中HLA—A1、A3、B8,Bw35,Cw6以及D Rw3抗原的基因频率比正常人明显增高,但不同地区的作者报告结果不一致,因不同种族的正常人群中HLA各位点抗原频率的分布有很大差异,因此可能影响到在不同种族中CAH的HLA抗原基因频率分布。在我国CAH较少见,但慢性迁延性肝炎(CPH)却较常见,其遗传易感性是否与细胞免疫系统中HLA的某些抗原有关?国内尚未见报道。在我国CPH病人中HLA抗原的分布是否与国外报告其它人
To study the relationship between chronic active hepatitis (CAH) and human leukocyte antigen (HLA) is an important aspect to study the genetic susceptibility of CAH. Since the 1970s, there have been many reports that the frequencies of HLA-A1, A3, B8, Bw35, Cw6 and Dww3 antigens in CAH patients were significantly higher than those in normal subjects. However, authors in different regions reported inconsistent results due to different ethnic The frequency distribution of HLA antigens in the normal population is very different and may affect the frequency distribution of HLA antigen genes of CAH in different ethnic groups. CAH is rare in our country, but chronic persistent hepatitis (CPH) is more common, and its genetic susceptibility is related to some antigens in the cellular immune system, HLA has not been reported in the country. In China, the distribution of HLA antigens in patients with CPH is reported by others