Immediately after the demonstration of the high-quality electronic properties in various two dimensional (2D) van der Waals (vdW) crystals fabricated with mechanical exfoliation,many methods have been reported to explore and control large scale fabrications.Comparing with recent advancements in fabricating 2D atomic layered crystals,large scale production of one dimensional (1D) nanowires with thickness approaching molecular or atomic level still remains stagnant.Here,we demonstrate the high yield production of a 1D vdW material,semiconducting Ta2Pd3Se8 nanowires,by means of liquid-phase exfoliation.The thinnest nanowire we have readily achieved is around 1 nm,corresponding to a bundle of one or two molecular ribbons.Transmission electron microscopy (TEM) and transport measurements reveal the as-fabricated Ta2Pd3Se8 nanowires exhibit unexpected high crystallinity and chemical stability.Our low-frequency Raman spectroscopy reveals clear evidence of the existing of weak inter-ribbon bindings.The fabricated nanowire transistors exhibit high switching performance and promising applications for photodetectors.