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Vasoactive intestinal polypeptide secreting tumors (VIPoma) are one kind of rare endocrine tumor which is mostly located in the pancreas.The annual incidence was estimated to be about 1 per 10 000 000 individuals in general population.1 The VIPoma is usually associated with Verner-Morrison syndrome following tremendous over-secretion of vasoactive intestinal polypeptide (VIP), which consisted of water diarrhea,hypokalemia and achlorhydria.This syndrome has been termed pancreatic cholera, watery diarrhea syndrome.