在疟疾流行区,大多数人感染疟原虫后无症状,只有少数人特别是儿童可出现症状,而发生严重病症如贫血和脑型疟者更少,其确切原因尚不清楚,寄生虫与宿主的遗传性状可能起一定的作用。本文的研究目的:1)确定不同的疟原虫抗原的体液反应是否为患脑型疟和温和型疟疾的重要决定因素;2)研究疟原虫基因型与体液反应之间的关系。 In malaria-endemic areas, most people are asymptomatic after being infected with the malaria parasite, and symptoms can occur in only a few people, especially in children. The exact cause is less clear for severe diseases such as anemia and cerebral malaria. The exact cause is not known. Parasites and hosts The genetic traits may play a role. The purpose of this study is to: 1) Determine whether the humoral response to different Plasmodium antigens is an important determinant of cerebral malaria and mild malaria; and 2) study the relationship between the genotype of Plasmodium and the humoral response.