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背景:近年来许多研究证明肿瘤坏死因子(TNF)-α和白细胞介素(IL)-6在炎症的发生中起重要作用。目的:研究克罗恩病(CD)患者血清TNF-α和IL-6水平的变化,探讨它们在CD发病中的作用。方法:以健康成人作为对照,用酶联免疫吸附测定(ELISA)方法测定CD活动期和缓解期患者的血清TNF-α和IL-6水平,同时测定血沉(ESR)、血小板计数和C反应蛋白(CRP)。结果:活动期CD患者的血清TNF-α和IL-6水平均显著高于缓解期患者和健康成人(TNF-α;P<0.05,IL-6:P<0.01),与ESR、血小板计数和CRP的变化一致。结论:TNF-α和IL-6在CD患者的炎症发生中起重要作用,可作为CD活动期的新标志物。
BACKGROUND: In recent years, many studies have demonstrated that tumor necrosis factor (TNF) -α and interleukin (IL) -6 play an important role in the pathogenesis of inflammation. Objective: To study the changes of serum TNF-α and IL-6 levels in Crohn’s disease (CD) patients and to explore their roles in the pathogenesis of CD. Methods: Serum levels of TNF-α and IL-6 in active and remission stage of CD patients were measured by enzyme-linked immunosorbent assay (ELISA) in healthy adults. ESR, platelet count and C-reactive protein (CRP). Results: Serum levels of TNF-α and IL-6 in active CD patients were significantly higher than those in remission patients and healthy adults (TNF-α; P <0.05, IL-6: CRP changes consistent. CONCLUSION: TNF-α and IL-6 play an important role in the inflammation of CD patients and can be used as new markers of CD activity.