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最近的研究表明,慢性HBV感染与肝细胞癌(HCC)的发生具有显著的相关。已有学者应用克隆HBV-DNA分子杂交技术证实大多数慢性HBsAg携带者的HCC患者其癌细胞的DNA上有HBV基因整合,同时HBV—DNA杂交顺序也可在HBsAg阴性的HCC患者癌细胞上发现,这些研究结果有力支持HBV在HCC中的致癌作用。作者还研究成功高亲和力的抗-HBs单克隆抗体,并用于敏感特异的放射免疫(RIA)来测定血清中的HBsAg相关抗原决定簇。这种单克隆RIA法
Recent studies have shown that chronic HBV infection has a significant correlation with the development of hepatocellular carcinoma (HCC). Some scholars have used cloned HBV-DNA molecular hybridization technology to confirm the HCC patients with most chronic HBsAg carriers of cancer cells DNA integration of HBV genes, HBV-DNA hybridization sequence can also be found in HbsAg-negative HCC cancer cells , These findings strongly support the carcinogenic effect of HBV in HCC. The authors also studied successful, high-affinity anti-HBs monoclonal antibodies and used them in the determination of HBsAg-associated antigenic determinants in serum using sensitive specific radioimmunoassays (RIA). This monoclonal RIA method