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目的了解小儿慢性肾衰竭(CRF)的病因构成、临床特点及其网织红细胞(Ret)参数的变化。方法收集2009年1月~2010年12月于我院住院的23例CRF患儿,男16例,年龄最小4个月,最大13岁;女7例,年龄最小9个月,最大15岁。对其病因、临床特点进行回顾性分析;用LH750血细胞分析仪检测肾性贫血患儿和正常儿童网织红细胞参数的变化。结果获得性肾小球疾病13例(55%),平均发病年龄12.25岁,确诊前病程平均1.56 a;先天性肾脏疾病10例(45%),平均发病年龄8.46岁,确诊前病程平均4.39 a。CRF主要临床表现为肾性贫血、高血压、电解质紊乱、代谢性酸中毒、生长发育迟缓和感染等等。经检测,肾性贫血患儿的网织红细胞百分比(Ret%)较正常组升高,但网织红细胞不成熟度(IRF)值基本正常或略低。结论我院小儿慢性肾衰竭病因主要以获得性肾小球疾病为主,对其网织红细胞各参数的检测,有利于了解肾性贫血患儿的骨髓增生程度和红系生长情况,为临床正确评估肾脏功能、及时用药提供参考价值。
Objective To investigate the etiology, clinical features and reticulocyte (Ret) parameters of children with chronic renal failure (CRF). Methods Twenty-three patients with CRF who were hospitalized in our hospital from January 2009 to December 2010 were collected. There were 16 males, the youngest being 4 months and the oldest being 13 years old. There were 7 females, the youngest 9 months and the oldest 15 years old. The etiology and clinical features were retrospectively analyzed. The LH750 hematology analyzer was used to detect the changes of reticulocyte parameters in children with renal anemia and normal children. RESULTS: Thirteen patients (55%) had acquired glomerular disease, with an average age of 12.25 years. The average duration of pre-diagnosis was 1.56 years. Ten cases (45%) had congenital kidney disease, with an average age of 8.46 years. . CRF main clinical manifestations of renal anemia, hypertension, electrolyte imbalance, metabolic acidosis, growth retardation and infection and so on. After testing, children with renal anemia reticulocyte percentage (Ret%) increased compared with the normal group, but the reticulocyte maturity (IRF) values were normal or slightly lower. Conclusion The main cause of chronic renal failure in our hospital is mainly acquired glomerular disease. The detection of reticulocyte parameters is helpful to understand the degree of myeloproliferation and erythroid growth in children with renal anemia, and is clinically correct Evaluation of renal function, timely medication provides a reference value.