5′—脱氧—5—氟尿苷(5′—DFUR)是一种新的氟尿嘧啶衍生物。抗肿瘤实验指出,5′—DFUR比其他的氟尿嘧啶具有较好的疗效、较低的毒性,是一颇有希望的抗肿瘤新药。本文用高效液相色谱法分离和检测了血液和组织中5′—DFUR的含量,研究了5′—DFUR在小白鼠体液内的动态过程,有助于分析该化合物在体内的吸收、分布、代谢等重要性质,并找出血药浓度与药效的确切关系。 5’-deoxy-5-fluorouridine (5’-DFUR) is a new fluorouracil derivative. Antitumor experiments indicate that 5’-DFUR has better curative effect and lower toxicity than other fluorouracil, which is a promising antitumor drug. In this paper, the content of 5’-DFUR in blood and tissues was isolated and detected by HPLC, the dynamic process of 5’-DFUR in body fluid of mice was studied, which is helpful to analyze the absorption, distribution, Metabolism and other important properties, and find out the exact relationship between blood concentration and efficacy.