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目的:探讨转移消失(missing in metastasis,MIM)基因在乳腺癌及癌旁组织中的表达及其与乳腺癌临床病理特征的关系。方法:采用SYBR Green实时定量PCR技术检测60例乳腺癌及癌旁组织MIM mRNA的表达,并分析其在不同临床参数间的表达差异。结果:MIM mRNA在乳腺癌中的表达高于癌旁组织(P<0.05),其表达与乳腺癌淋巴结转移(P<0.01)、肿物大小和TNM分期密切相关(P<0.05),但与年龄、组织学分级、病理类型、雌激素受体、孕激素受体、细胞表面生长因子受体以及细胞增殖核抗原表达无关(P>0.05)。结论:MIM的过表达参与乳腺癌的转移,并可能是乳腺癌中晚期的有效预测指标,有望成为乳腺癌治疗的新靶点。
OBJECTIVE: To investigate the expression of missing in metastasis (MIM) genes in breast cancer and adjacent tissues and its relationship with clinicopathological features of breast cancer. Methods: SYBR Green real-time quantitative PCR was used to detect the expression of MIM mRNA in 60 cases of breast cancer and its adjacent tissues. The expression of MIM mRNA in different tissues was analyzed. Results: The expression of MIM mRNA in breast cancer was higher than that in adjacent tissues (P<0.05). The expression of MIM mRNA was closely related to lymph node metastasis (P<0.01), tumor size, and TNM stage (P<0.05). Age, histological grade, pathological type, estrogen receptor, progesterone receptor, cell surface growth factor receptor, and cell proliferating nuclear antigen were not related (P>0.05). Conclusion: Overexpression of MIM is involved in the metastasis of breast cancer, and may be an effective predictor of advanced breast cancer. It may be a new target for breast cancer treatment.